BAY 1024767

Research use only, not for human use.

BAY 1024767 (BAY1024767) is a higly potent antagonist of androgen receptor (AR) wild-type (IC50=46 nM) and mutant forms located in the AR ligand-binding domain (LBD).

BAY 1024767 (BAY1024767) is a higly potent antagonist of androgen receptor (AR) wild-type (IC50=46 nM) and mutant forms located in the AR ligand-binding domain (LBD); inhibits mutants L701H, E709Y, V715M, W741C, H874Y (IC50=31 nM), F876L, T877A, M895T and M895V (IC50=11 nM); promotes nuclear localization of AR wild-type and mutants in the absence of R1881 in COS-7 cells; demonstrates KuCaP-1 prostate cancer model which bears the W741C bicalutamide resistance mutation and in the syngeneic prostate cancer rat model Dunning R3327-G.

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BAY1024767

Endocrinology/Hormones

Androgen Receptor (AR)

Androgen Receptor (AR)

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1273068-71-5

492.517

C23H23F3N4O3S

>98% (HPLC)

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4-(3-((6-(2-hydroxy-2-methylpropoxy)pyridin-3-yl)methyl)-4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile

(-20℃)

With Ice Pack

≥ 2 years